Analysis performed on 2024-07-10 11:40:01
| Initial | Filtered Out | Final | Blast | |
|---|---|---|---|---|
| Bacteria | 47200 | 503 | 46697 | 17863 |
| Archaea | 3403 | 83 | 3320 | 1423 |
| Vertebrata | 1311 | 217 | 1094 | 497 |
| Mammals | 536 | 75 | 461 | 126 |
| Protein Length | Pathogenic Variants | Benign/Unknown Variants |
|---|---|---|
| 471 | 26 | 315 |
| Domains | |
|---|---|
| Current Study | 1, 52 |
| Guo et al (2010) | 8, 64 |
| Ancient Domains | Modern Domains | All | Ratio | |
|---|---|---|---|---|
| Number of Residues | 420 | 51 | 471 | 8.235294 |
| Number of Variants | 296 | 45 | 341 | 6.577778 |
| Number of Pathogenic Variants | 22 | 4 | 26 | 5.500000 |
| Number of Benign/Unknown Variants | 274 | 41 | 315 | 6.682927 |
| Fisher exact test | 0.761847 |
The Fisher exact test was calculated using a contingency table with the number of pathogenic and benign/unknown variants in ancient and modern domains. The bottom left values.
| Ancient Domains | Modern Domains | All | Ratio | |
|---|---|---|---|---|
| Number of Residues | 414 | 57 | 471 | 7.263158 |
| Number of Variants | 288 | 53 | 341 | 5.433962 |
| Number of Pathogenic Variants | 21 | 5 | 26 | 4.200000 |
| Number of Benign/Unknown Variants | 267 | 48 | 315 | 5.562500 |
| Fisher exact test | 0.575133 |
The Fisher exact test was calculated using a contingency table with the number of pathogenic and benign/unknown variants in ancient and modern domains. The bottom left values.
| # of sites Ancient | # sites Modern | Mean Ancient (SD) | Mean Modern (SD) | Median Ancient | Median Modern | Mann-Whitney U | p-value | |
|---|---|---|---|---|---|---|---|---|
| Current Study | 420 | 51 | 0.89 (0.01) | 0.78 (0.02) | 9.503e-01 | 7.752e-01 | 15221.50 | 4.44e-07 |
| Guo et al (2010) | 414 | 57 | 0.89 (0.01) | 0.81 (0.02) | 9.502e-01 | 8.050e-01 | 15775.50 | 1.84e-05 |
The Mann-Whitney U test was calculated using the conservation scores of the amino acids in ancient and modern domains. The p-value is for the null hypothesis that the conservation scores in ancient domains are greater than in modern domains.